San Diego's a big place, any idea what part of town you will be in? La Jolla is really nice, downtown would also be good. The Gaslamp District is the coolest part of town for nightlife, but may be a headache for clients to get into and out of. There's also Mission Valley or North County (Del Mar, Cardiff, etc) if you want a more layed back, beachey vibe...

NSF

I usually like to stay at the Marriott Hotel and Marina. It's a little pricey (at least from my perspective), but the rooms are beautiful, very well maintained, with great views, great service, and is very close to the Gaslamp district. While I've never stayed there, the Hyatt right next door is also very nice. One place that I wouldn't really recommend would be the Wyndham Emerald Plaza. I stayed there my last time in town, and was not really impressed.
Hope this helps. Love your site and I'd like to meet you the next time I'm in Vegas!

-- Modified on 10/6/2006 6:58:25 PM

that you should avoid hotels in the "Hotel Circle" area.  Wherever the heck that is.