I'm not crazy regular, but I'll throw in what I've seen.
Pretty close to dead on Monday-(Wednesday?). Last time I was in town, the food court at Caesar's was closed, for instance. Pushing you hard towards the nicer restaurants, which I don't mind, but that might matter to some. As far as strip clubs, Sapphires was open 7 days, but Rhino is only open Thursday-Saturday. Other clubs might not be open at all, or open 7 days a week, or only open 3 days a week.
There are some dance (not stripper) clubs that have announced they're opening in March/April. I'd look into which clubs you're interested in and check the social media of each.
Some hotels, like Wynn, aren't open Monday-Wednesday, last I heard.
Seriously, the vibe is very different. Not trying to be an a-hole, here, but the people in town are not the people who visited in the past. It's amateur hour in Vegas right now. Lots of really cheap people, and not a lot of people who know how to tip well, etc.
I mean, it's worth going to because nowhere else is any better right now, except maybe Florida/Miami (?). Everywhere I've been, it's pretty much the same. Vegas is better than those places, if you're comparing 2021 in City X vs 2021 in Vegas, but it's nothing like 2019 Vegas, you know?