It's always better to mix it up between the different areas on the first trip to gauge where the most interest comes as well as get a general feel for the area. Tyson's is the default choice but don't discount the Arlington area as it offers the best of both worlds - Metro accessibility as well as parking in addition to having some really great hotels. The Dupont area is the normal choice of ladies visiting DC, to get a change of pace look south of the circle even over toward Thomas Circle as there are some great hotels that I won't go so far as to say hobby friendly but certainly are aware of what's going on and not uptight about it.