I am using Spybot and Ad-Aware, but still have tons of spam.  And, yes, do keep all up-to-date almost daily.
Using the above, do you suggest Norton Internet Security 2006 would stop spam (for the most part) altogether?
With all I have already, I still get too darn much spam and am sick, sick, sick of it.

great; you can tag spam senders as spam, then all future email from them is canned; likewise you can have approved senders who's email always gets thru.  You can even label as spam everything from large spam originators - e.g. domains ending with .ru or yahoo.com, hotmail.com, google.com

I agree about Norton Internet Security 2006.  However, don't overlook the Junk filter built into Outlook 2003.  After I switched from Outlook Express, I was amazed at how many appropriate e-mails Outlook 2003 automatically put into the Junk file. Running both Norton and 2003, the 2003 is catching about 8 times as many junk items as Norton does.  That's not to indict Norton - it may be the Outlook gives its own Junk system first crack at the catch, and then Norton catches the rest.  But I like having both.  They intergrate together very well.