Watch out for the AIDS vaccine.  The initial clincial trials showed only muted efficacy in the smallest racial groups in the study.  The problem with HIV is we are seeing that the mutations that occur from the medication failures are being transmitted to new infectees.  In other words instead of getting the wild type (+) strain and having the full component of meds available some new infectees are starting behind the 8-ball with a limited number of medications.  Therefore, in the vaccine is not going to be able to protect against mutated HIV viruses.  It's possible niche will be in newly infected areas where the wild type HIV virus is dominant.