I know CL has a bad reputation, but I am in Mayberry, and it is the only game in town. Anyone have any advice on what to look for or look out for when using a CL girl with no reviews?

At the very least, plug her phone # back into the search function and see what other ads or replies come up. Do a reverse directory search on the #, too. I wouldn't go anywhere for incall except a hotel without the room doors exposed to view in the parking lot. I'd also take a drive around your local police dept parking lot at about 8:00 AM when most of the undercover cars are there and see what they use so you can look out for them. I'd also let a trusted friend know what you're doing and the room # and tell him you'll call him when you're done. If you get there and it feels wrong leave. May sound paranoid but none of it will hurt you.

I've had a whole host of bad experiences with the cheap hos you'll find on CL.  I would never again spend money on one unless they had gotten a bunch of good reviews on TER.  The vast majority of girls there hate what they do and have no interest in showing you a good time.

This should tell you everything you need to know about using Craigslist. This is by no means exclusive to Chicago either!