Hi Jeff, Thanks for your reply! If I go to Costco to get HPV vaccine, I bet the people there will immediately know I going to develop a hobby.
Posted By: JeffEng16
You raised a good question that I've heard asked by a lot of people for years.
If you read further down in the article or the the other medical literature on the bivalent and quadrivalent vaccines
The reason is because in many trials conducted during the N.D.A.s (New Drug Application process progressing from a small number of hospital beds in an experimental setting to large numbered trials towards the end conducted by physicians in their offices who agree to follow certain requirements and standards for testing and to do the paper work to report a number of results of administering the new drug "candidate") to get approval for the bivalent and quadrivalent vaccines in men and women, the vaccine ******was not effective in preventing HPV over age 26*****. It was safe, but not an effective vaccine over that age.
Why efficacy falls off at that age is not known.
But there is another very important important point that pushes the recommendation for administering down to the ages of pre-teens besides that maximal efficacy happens at an earlier age in scores of trials. The target age for giving the vaccine is around 9-12 years of age because after the onset of sexual activity (and whatever it is for most individuals it's getting younger all the time), the individual may have already been infected with HPV.
From the American College of Obstetrics and Gynecology's statement or "ACOG"
"In Sweden, data that linked multiple population registers showed that vaccine effectiveness in preventing genital warts was 93% among girls vaccinated between ages 10 years and 13 years compared with 48% and 21% if vaccinated at ages 20–22 years and 23–26 years, respectively (15). Data from the United States show that 1 month after the completion of HPV vaccination, girls aged 10–14 years generally have higher antibody levels than young women aged 15–26 years and retain these higher levels for several years (16, 17). All of these findings underscore the importance of vaccination during the target age or before the onset of sexual activity."
The CDC does a lousy job by inserting one sentence alluding to that in their whole article. Maybe that's why the're advertising for writers for their website who can explain their concepts right now.
