try midtown-  lots of large hotels to choose from anywhere from 42nd to 60th

Both should be crossed off your list, as they are obviously compromised.  While I would recommend midtown, where there are dozens of excellent hotels to choose from, I would do research to determine which places fit the bill in terms of amenities and pricing during the dates you are planning to visit.   Use the national travel sites to do that, and ask other providers that you know who either visit or live here for recommendations.  Midtown is the best location for both yourself and your clients...the latter can get there easily, and you have access to many nearby quality restaurants, shopping, and transit to other places in the City that you might wish to visit or explore.

It's a world of laughter, A world of tears.

True story

I'm swapping emails and making plans to meet a gal in NYC and as the details emerge, it turns out we are both staying at the same hotel.

Maybe a better subject line would have been "My place or yours?"

I don't use them, but I know someone on another board who uses this discount hotel booking service when setting up outcall appointments in the city (he's married, so he can't invite providers to his home). It's called quickbook dot com. They have deals with tons of New York properties, and from time to time even some of the boutique hotels turn up on their list.

east side (Mad, Park, Lex, 3rd, 2nd, 1st, & York aves) tend to be more convienent to many hobbists. I've always found midtown on the West side to be more problematic (tunnel traffic/Times Sq/Tourist).

http://maps.google.com/maps?q=Hotels+near+Midtown,+New+York,+NY&um=1&ie=UTF-8&sa=N&hl=en&tab=wl

Tourists and businesspeople...

Lots of variety and foot traffic.