There are dozens of fine hotels to choose from, it's centrally located so it's both convenient for clients to visit, and for you re: shopping, restaurants, bars, and if you need transportation to get to other points of interest in the City.  Be sure to check out the hotels on the web in order to get the deal you need in terms of amenities, cost, and location.  If being within walking distance of Central Park is important to you, best you favor locales on the Upper West Side.  Best of luck!

Priceline different parts of midtown (east and west) or times square or soho area, etc see what 3.5, 4 star hotels are going for.