I don't know if you mean an agency that makes appointments for their staff at numerous distributed satellite locations (apartments, hotels, motels, ...). Or do you mean MPs with a fixed geographic location and a rotating group of staff members?
If the former, it might just be the booker / phone girl who is, in fact, on vacation and someone else (different number) is doing the scheduling for now.
If the latter, I can only think of NYC. Once a while, a shop (often in commercial space) will close in order to do elective renovations: upgrade plumbing for a new washing machine or table shower room; upgrade electric to avoid a code violation

; new furniture; partitions, painting, etc.. If there was trouble in the building (a fire in the pizza shop below - actually happened; a burst frozen water pipe; almost anything), they have to close to fix things up.
If you are referring to an ad or phone number for a specific agency WITHOUT visiting their geographic location, it might be that they lost their lease or got busted. Now, they are on "vacation" scrambling for a new apartment or loft which likely needs to be upgraded to KMP quality (plumbing, table shower, etc.). So far, you're talking about 2-3 weeks; a not unreasonable time to get building permits and to get the job done.
When you reconnect to the same number, you might find yourself being told to go to a new location.
Posted By: mangoballs78
A K-girl agency in my area has been on "vacation" since Christmas. Is it typical for an Agency to be on vacation for this time of length? Not that I don't think they deserve a vacation but just wondering. I will admit that I'm getting antsy to see what talent they bring next