If your going to use it for that first time with a lady you might want to tell her encase you have reaction to the pill.
But after the first time and you know you won't have an reaction to it, then I don't think you need to worry about it.
The more important things you need to worry about is are.
Cost, these are not cheap pill and if you don't have a great prescription plan, it going to cost big bucks.
Your best and cheapest bet, might be to have the Doc give you a prescription for 100mg pills and cut them in half,
you buy less pills, but they last longer. Some prescription plan will only cover the cost of a few pills, so this will help.
Reaction time, Everybody is different, so you need to know how long will it take for the pills to work, most say 30 to 45 minutes before having sex. But after a few time you should have a better idea what time frame works best for you.
Beside you don't want the pill working 20 minutes after the appointment is over, Now that would suck.
Also a little story I heard that might help to, since some of the reaction to the pill, might be a stiff neck or back, I have heard that some guys take Advil before they take the blue pill to help stop the stiff neck or back. But you will still get stiff were you want to be.