Sent you an email!

In terms of coming off the highway, and the number and quality of hotels and other amenities.   But, of course, it is the most expensive.

 
The airport hotels are a good bargain, and easy to get to, but not much to do out there.   Same is true with the hotels along I-95.

 
Downtown, waterfront, the Seaport District, and the North End are hard to get to, but have a lot of things to do in those neighborhoods.   They can be pricey sometimes, but some hotels there are bargains.

I haven't posted a Boston Neighborhood Map in a while. Copley is a smaller sub-neighborhood within the large yellow Back Bay section.  The Airport, mentioned by some, is in East Boston (far right). It's not as isolated as it looks: public transit and tunnels make the connection to downtown doable.
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Someone mentioned Metrowest. The scale of this map is too small to show it; MW would be around 10 miles west. Using google maps, look for the intersection of US 90 (east-west) and US 95 (north-south).

Here's another one. Don't worry, it's from a real estate company, not a hotel room rental company. Those aren't the room rates!
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Don't worry about minor differences, e.g., Midtown? I never knew Boston had a Midtown. If someone wants to know your location, a few streets off isn't a big deal to narrow things down.  Is Lincoln St. Leather District or Chinatown? It doesn't matter, because either of those neighborhood names gives your approximate location to a prospective visitor. If he can make it to C-Town, he can make it to LD.