There are three areas that are most popular (IMHO). In no particular order:
A) Downtown/Gaslamp/Convention Center, lots of very nice to medium quality hotels with amble parking choices. When you're not hosting restaurants, shopping, etc are walking distance. Waterfront locations but no beach.
B) Mission Valley/Hotel Circle. More inland, but all major highways kind of converge. Lots of hotel choices but IMHO discrete parking can be a challenge for your potential guests, depending on the hotel. Plenty of restaurants and shopping nearby, but you'll drive from place to place.
C) Del Mar/Carmel Valley, just north of San Diego (20 minutes north of the airport/downtown). Fewer choices but nice hotels and resorts. When you're not entertaining a guest, the beaches are close.

I left out LaJolla (beautiful, but too hard to get in and out of) and North County Coastal areas (Carlsbad, LaCosta, and Oceanside) just because a lot of people think its "too far."

enjoy your visit!

Posted By: misslearayne

I am planning a visit to SD in early November. Could you please help with the best, most convenient location for incall?  
 Not very familiar with the area. Visiting from NYC. PM or email is good, or post here if ok  
   
 Thanks a lot in advance  
 Sincerely  
 Lea  

Is San Diego

A public trans/walking city?   I'm also going to be in SD for a wedding and planning on staying a few extra days to hobby provide...

Mission Bay: several nice hotels located right on water. Safe.
Mission Valley: had many dates there with no problems either parking or LE. Safe.
Do not like downtown due to traffic and parking issues.
Hope you enjoy our beautiful city.